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How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease QUOTES

190 " A few thousand years later, scientists finally put saffron to the test in a head-to-head trial against the antidepressant drug Prozac for the treatment of clinical depression. Both the spice and the drug worked equally well in reducing depression symptoms.44 As you can see in the box here, this may not be saying much, but at the very least, the saffron was safer in terms of side effects. For example, 20 percent of people in the Prozac group suffered sexual dysfunction, a common occurrence with many antidepressant medications, whereas no one in the saffron group did. However, saffron may be one of those rare cases in which the natural remedy is more expensive than the drug. Saffron is the world’s most expensive spice. It is harvested from crocus flowers, specifically the dried stigmas (the threadlike tips inside the flower), which are ground up to make the spice. You need more than fifty thousand crocuses—enough to cover a football field—to produce just a single pound of saffron.45 A Prozac-equivalent dose of saffron may cost more than twice as much as the drug, but a subsequent study found that even just smelling saffron appeared to have psychological benefits. Though researchers diluted the spice so much that the study subjects couldn’t detect its odor, they still noted a significant drop in stress hormones measured in women who sniffed the saffron for twenty minutes compared with those who spent twenty minutes smelling a placebo, along with significant improvement in the women’s symptoms of anxiety. "

Michael Greger , How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease