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21 " is bound by pratityasamutpada, the twelve-membered chain of causality. And the first link in this chain is ignorance. Ignorance starts the chain that binds the soul to the cycle of rebirth and suffering. Only when ignorance is overcome (through learning what the events in our lives have to teach us!) can we liberate ourselves from starting the cycle yet one more time and so finally achieve nirvana. "
― , Everything Happens for a Reason: Finding the True Meaning of the Events in Our Lives