143
" In medicine, we are often confronted with poorly observed and indefinite facts which form actual obstacles to science, in that men always bring them up, saying: it is a fact, it must be accepted. CLAUDE BERNARD, An Introduction to the Study of Experimental Medicine, 1865 "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease
147
" In 1975, Richard Doll and Bruce Armstrong published a seminal analysis of diet and cancer, in which they noted that, the higher the sugar intake in different nations, the higher both the incidence of and mortality from cancer of the colon, rectum, breast, ovary, uterus, prostate, kidney, nervous system, and testicles. "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease
154
" excess weight and obesity, like all diseases of civilization, are caused by the singular hormonal effects of a diet rich in refined and easily digestible carbohydrates. The fattening of our adult years, after all, is not just associated with chronic diseases of civilization, it is a disease of civilization, and so it, too, may be a symptom of an underlying disorder. In this hypothesis, it is the quality of the calories consumed that regulates weight, and the quantity—more calories consumed than expended—is a secondary phenomenon. "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease
155
" A resolution of the very controversial question of the efficacy of low carbohydrate diets has great practical and theoretical significance,” wrote Donald Novin of UCLA in 1978. Because a generation of obesity authorities were determined to dismiss the practical significance of carbohydrate-restricted diets, they dismissed the potential theoretical significance at the same time. Obesity researchers today say they still have no hypothesis of weight regulation that can explain obesity and leanness, let alone account for a century of paradoxical observations. They insist that obesity is inevitably caused by overeating and thus consuming more calories than we expend, but when asked what causes someone to overeat, they have no answer. Yet the research on insulin and fat metabolism offers one, and it has for several decades. "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease
157
" In Type 1 diabetes, the cause is a lack of insulin. The result is an inability to use glucose for fuel and to retain fat in the fat tissue, leading to internal starvation, as Astwood put it, excessive hunger, and weight loss. In obesity, the cause is an excess of insulin or an inordinate sensitivity to insulin by the fat cells; the result is an overstock of fuel in the adipose tissue and so, once again, internal starvation. But now the symptoms are weight gain and hunger. In obesity, the weight gain occurs with or without satisfying the hunger; in Type 1 diabetes, the weight loss occurs irrespective of the food consumed. This "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease
159
" The vitamin-C molecule is similar in configuration to glucose and other sugars in the body. It is shuttled from the bloodstream into the cells by the same insulin-dependent transport system used by glucose. Glucose and vitamin C compete in this cellular-uptake process, like strangers trying to flag down the same taxicab simultaneously. Because glucose is greatly favored in the contest, the uptake of vitamin C by cells is “globally inhibited” when blood-sugar levels are elevated. In effect, glucose regulates how much vitamin C is taken up by the cells, according to the University of Massachusetts nutritionist John Cunningham. If we increase blood-sugar levels, the cellular uptake of vitamin C will drop accordingly. Glucose also impairs the reabsorption of vitamin C by the kidney, and so, the higher the blood sugar, the more vitamin C will be lost in the urine. Infusing insulin into experimental subjects has been shown to cause a “marked fall” in vitamin-C levels in the circulation. In "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease
160
" The USDA statistics, however, were based on guesses, not reliable evidence. These statistics, known as “food disappearance data” and published yearly, estimate how much we consume each year of any particular food, by calculating how much is produced nationwide, adding imports, deducting exports, and adjusting or estimating for waste. The resulting numbers for per-capita consumption are acknowledged to be, at best, rough estimates. "
― Gary Taubes , Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control, and Disease