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1 " I am wired to live joy in all ways. I let my being be healed and tended by the high vibration of joy. My life is optimized for boundless joy. "
― Amy Leigh Mercree , Joyful Living: 101 Ways to Transform Your Spirit and Revitalize Your Life
2 " The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution. "
― , Viruses: Agents of Evolutionary Invention
3 " Abstraction automatically gives rise to optimized solutions within the universal set of all possible solutions, as has been shown in this book. It is these optimized solutions that make up and drive the non-abstract parts of the world, while the non-optimized solutions remain ‘hidden’ from the material world, inside the abstract world.Starting from a basis of no postulation, we build our theory. As we go on piling up possibilities, we come to a similar basis for understanding the four non-contact forces of nature known till date. The difference in ranges of these forces is explained from this basis in this book. Zero postulation or abstraction as the basis of theory synthesis allows us to explore even imaginary and chaotic non-favoured solutions as possibilities. With no postulation as the fundamental basis, we are thus able to pile up postulated results or favoured results, but not the other way round. We keep describing such implications of abstraction in this book. We deal with the abstraction of observable parameters involved in a given system "
― Subhajit Ganguly
4 " Thinking outside the box only works if you know everything inside it. Don’t compare your chapter 1 to someone else’s chapter 20. That’s the biggest mistake young entrepreneurs do and end up getting disappointed. The ones you call conventional are the business models, which have been optimized and modified at various stages over a long period of time. You need to work hard and be a bit more patient. "
5 " Societies would _not_ be better off if everyone were like Mr Spock, all rationality and no emotion. Instead, a balance - a teaming up of the internal rivals - is optimal for brains. ... Some balance of the emotional and rational systems is needed, and that balance may already be optimized by natural selection in human brains. "
― David Eagleman , Incognito: The Secret Lives of the Brain
6 " Some websites are completely optimized for simple conversion, and it’s easy to tell. The design centers on one clear call to action, a vivid lozenge labeled with a verb. "
― Erika Hall , Just Enough Research
7 " Some websites are completely optimized for simple conver- sion, and it’s easy to tell. The design centers on one clear call to action, a vivid lozenge labeled with a verb. "