65
" All depression has its roots in self-pity, and all self-pity is rooted in people taking themselves too seriously." At the time Switters had disputed her assertion. Even at seventeen, he was aware that depression could have chemical causes." The key word here is roots," Maestra had countered. " The roots of depression. For most people, self-awareness and self-pity blossom simultaneously in early adolescence. It's about that time that we start viewing the world as something other than a whoop-de-doo playground, we start to experience personally how threatening it can e, how cruel and unjust. At the very moment when we become, for the first time, both introspective and socially conscientious, we receive the bad news that the world, by and large, doesn't give a rat's ass. Even an old tomato like me can recall how painful, scary, and disillusioning that realization was. So, there's a tendency, then, to slip into rage and self-pity, which if indulged, can fester into bouts of depression." " Yeah but Maestra - " " Don't interrupt. Now, unless someone stronger and wiser - a friend, a parent, a novelist, filmmaker, teacher, or musician - can josh us out of it, can elevate us and show us how petty and pompous and monumentally useless it is to take ourselves so seriously, then depression can become a habit, which, in tern, can produce a neurological imprint. Are you with me? Gradually, our brain chemistry becomes conditioned to react to negative stimuli in a particular, predictable way. One thing'll go wrong and it'll automatically switch on its blender and mix us that black cocktail, the ol' doomsday daiquiri, and before we know it, we're soused to the gills from the inside out. Once depression has become electrochemically integrated, it can be extremely difficult to philosophically or psychologically override it; by then it's playing by physical rules, a whole different ball game. That's why Switters my dearest, every time you've shown signs of feeling sorry for yourself, I've played my blues records really loud or read to you from The Horse's Mouth. And that's why when you've exhibited the slightest tendency toward self-importance, I've reminded you that you and me - you and I: excuse me - may be every bit as important as the President or the pope or the biggest prime-time icon in Hollywood, but none of us is much more than a pimple on the ass-end of creation, so let's not get carried away with ourselves. Preventive medicine, boy. It's preventive medicine." " But what about self-esteem?" " Heh! Self-esteem is for sissies. Accept that you're a pimple and try to keep a lively sense of humor about it. That way lies grace - and maybe even glory. "
66
" This is the great lesson the depressive learns: Nothing in the world is inherently compelling. Whatever may be really “out there” cannot project itself as an affective experience. It is all a vacuous affair with only a chemical prestige. Nothing is either good or bad, desirable or undesirable, or anything else except that it is made so by laboratories inside us producing the emotions on which we live. And to live on our emotions is to live arbitrarily, inaccurately—imparting meaning to what has none of its own. Yet what other way is there to live? Without the ever-clanking machinery of emotion, everything would come to a standstill. There would be nothing to do, nowhere to go, nothing to be, and no one to know. The alternatives are clear: to live falsely as pawns of affect, or to live factually as depressives, or as individuals who know what is known to the depressive. How advantageous that we are not coerced into choosing one or the other, neither choice being excellent. One look at human existence is proof enough that our species will not be released from the stranglehold of emotionalism that anchors it to hallucinations. That may be no way to live, but to opt for depression would be to opt out of existence as we consciously know it. "
― Thomas Ligotti , The Conspiracy Against the Human Race
67
" You see, people in the depressive position are often stigmatised as ‘failures' or ‘losers'. Of course, nothing could be further from the truth. If these people are in the depressive position, it is most probably because they have tried too hard or taken on too much, so hard and so much that they have made themselves ‘ill with depression'. In other words, if these people are in the depressive position, it is because their world was simply not good enough for them. They wanted more, they wanted better, and they wanted different, not just for themselves, but for all those around them. So if they are failures or losers, this is only because they set the bar far too high. They could have swept everything under the carpet and pretended, as many people do, that all is for the best in the best of possible worlds. But unlike many people, they had the honesty and the strength to admit that something was amiss, that something was not quite right. So rather than being failures or losers, they are just the opposite: they are ambitious, they are truthful, and they are courageous. And that is precisely why they got ‘ill'. To make them believe that they are suffering from some chemical imbalance in the brain and that their recovery depends solely or even mostly on popping pills is to do them a great disfavour: it is to deny them the precious opportunity not only to identify and address important life problems, but also to develop a deeper and more refined appreciation of themselves and of the world around them—and therefore to deny them the opportunity to fulfil their highest potential as human beings. "
― Neel Burton
69
" Depression, we are told over and over again, is a brain disease, a chemical imbalance that can be adjusted by antidepressant medication. In an informational brochure issued to inform the public about depression, the US National Institute for Mental Health tells people that 'depressive illnesses are disorders of the brain' and adds that 'important neurotransmitters - chemicals that brain cells use to communicate - appear to be out of balance'. This view is so widespread that it was even proffered by the editors of PLoS [Public Library of Science] Medicine in their summary that accompanied our article. 'Depression,' they wrote, 'is a serious medical illness caused by imbalances in the brain chemicals that regulate mood', and they went on to say that antidepressants are supposed to work by correcting these imbalances.
The editors wrote their comment on chemical imbalances as if it were an established fact, and this is also how it is presented by drug companies. Actually, it is not. Instead, even its proponents have to admit that it is a controversial hypothesis that has not yet been proven. Not only is the chemical-imbalance hypothesis unproven, but I will argue that it is about as close as a theory gets in science to being dis-proven by the evidence. "
― , The Emperor's New Drugs: Exploding the Antidepressant Myth
71
" I feel . . . low," I say, looking away. " Like, literally low. Flat. It's not . . . sad, exactly. I mean, sad too, obviously. But that's a different feeling, I guess." She nods. " There's a reason it's called 'depression' and not 'chronic sadness' or 'manic sorrow.'" She picks up a foam stress ball and squeezes it, leaving imprints of her fingers. " Depressions like these are holes left behind by a physical force. With mental depression, the force can be chemical or situational or both, but it doesn't just make a hole--it presses you into one that feels impossible to escape. "
79
" You know when you send a text message to someone and you don't get a response right away, you feel depressed? You send a text message to someone you really like and you get a response right away you feel happy? You feel happy, the body, it creates the chemical dopamine, the dopamine, it goes through your blood and you become addicted to that dopamine rush, and you associate that dopamine rush with the happy feeling of receiving the text, and that's why you got people sending 3,000 fucking text messages a day, right, we're not even paying attention to what we're saying anymore it's just like a, like a morphine drip, right, it's like a dopamine drip! HAPPY BUTTONS! HAPPY BUTTONS! HAPPY BUTTONS! TIME TO PLAY WITH THE HAPPY BUTTONS! "
80
" Concepts of memory tend to reflect the technology of the times. Plato and Aristotle saw memories as thoughts inscribed on wax tablets that could be erased easily and used again. These days, we tend to think of memory as a camera or a video recorder, filming, storing, and recycling the vast troves of data we accumulate throughout our lives. In practice, though, every memory we retain depends upon a chain of chemical interactions that connect millions of neurons to one another. Those neurons never touch; instead, they communicate through tiny gaps, or synapses, that surround each of them. Every neuron has branching filaments, called dendrites, that receive chemical signals from other nerve cells and send the information across the synapse to the body of the next cell. The typical human brain has trillions of these connections. When we learn something, chemicals in the brain strengthen the synapses that connect neurons. Long-term memories, built from new proteins, change those synaptic networks constantly; inevitably, some grow weaker and others, as they absorb new information, grow more powerful. "
― Michael Specter
