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5 " In response to threat and injury, animals, including humans, execute biologically based, non-conscious action patterns that prepare them to meet the threat and defend themselves. The very structure of trauma, including activation, dissociation and freezing are based on the evolution of survival behaviors. When threatened or injured, all animals draw from a " library" of possible responses. We orient, dodge, duck, stiffen, brace, retract, fight, flee, freeze, collapse, etc. All of these coordinated responses are somatically based- they are things that the body does to protect and defend itself. It is when these orienting and defending responses are overwhelmed that we see trauma.The bodies of traumatized people portray " snapshots" of their unsuccessful attempts to defend themselves in the face of threat and injury. Trauma is a highly activated incomplete biological response to threat, frozen in time. For example, when we prepare to fight or to flee, muscles throughout our entire body are tensed in specific patterns of high energy readiness. When we are unable to complete the appropriate actions, we fail to discharge the tremendous energy generated by our survival preparations. This energy becomes fixed in specific patterns of neuromuscular readiness. The person then stays in a state of acute and then chronic arousal and dysfunction in the central nervous system. Traumatized people are not suffering from a disease in the normal sense of the word- they have become stuck in an aroused state. It is difficult if not impossible to function normally under these circumstances. "

13 " Opposition to animal research ranges considerably in degree. “Minimalists” tolerate animal research under certain conditions. They accept some kinds of research but wish to prohibit others depending on the probable value of the research, the amount of distress to the animal, and the type of animal. (Few people have serious qualms about hurting an insect, for example.) They favor firm regulations on research.

The “abolitionists” take a more extreme position and see no room for compromise. Abolitionists maintain that all animals have the same rights as humans. They regard killing an animal as murder, whether the intention is to eat it, use its fur, or gain scientific knowledge. Keeping an animal (presumably even a pet) in a cage is, in their view, slavery. Because animals cannot give informed consent to research, abolitionists insist it is wrong to use them in any way, regardless of the circumstances. According to one opponent of animal research, “We have no moral option but to bring this research to a halt. Completely. . . . We will not be satisfied until every cage is empty” (Regan, 1986, pp. 39–40). Advocates of this position sometimes claim that most animal research is painful and that it never leads to important results. However, for a true abolitionist, neither of those points really matters. Their moral imperative is that people have no right to use animals, even if the research is useful and even if it is painless.

The disagreement between abolitionists and animal researchers is a dispute between two ethical positions: “Never knowingly harm an innocent” and “Sometimes a little harm leads to a greater good.” On the one hand, permitting research has the undeniable consequence of inflicting pain or distress. On the other hand, banning the use of animals for human purposes means a great setback in medical research as well as the end of animal-to-human transplants (e.g., using pig heart valves to help people with heart diseases) (Figure 1.12). "

James W. Kalat