Home > Topic > a phenomenon
21 " Somatic hypermutation gives rise to B cells bearing mutant immunoglobulin molecules on their surface. Some of these mutant immunoglobulins have substitutions in the antigen-binding site that increase its affinity for the antigen. B cells bearing these mutant high-affinity immunoglobulin receptors compete most effectively for binding to antigen and are preferentially selected to mature into antibody-secreting plasma cells. The mutant antibodies that emerge from the selection do not have a random distribution of amino-acid substitutions. The changes are concentrated at positions in the heavy-chain and light-chain CDR loops that form the antigen-binding site and directly contact antigen. As the adaptive immune response to infection proceeds, antibodies of progressively higher affinity for the infecting pathogen are produced – a phenomenon called affinity maturation. Affinity maturation is a process of evolution in which variant immunoglobulins generated in a random manner are subjected to selection for improved binding to a pathogen. It achieves in a few days what would require thousands, if not millions, of years of classical Darwinian evolution in a conventional gene. This capacity for extraordinarily rapid evolution in pathogen-binding immunoglobulins is a major factor in allowing the human immune system to keep up with the generally faster-evolving pathogens. "
― , The Immune System
22 " The recurrence of a phenomenon like [Thomas] Edison is not very likely. The profound change of conditions and the ever increasing necessity of theoretical training would seem to make it impossible. He will occupy a unique and exalted position in the history of his native land, which might well be proud of his great genius and undying achievements in the interest of humanity. "
― Nikola Tesla
23 " Curt, my husband, is a writer, and he’ll never write again. That’s our funeral, as they say down south. Now in your case, my pet, you’re married to a phenomenon of our own special epoch, a man who couldn’t in a thousand years be a writer in the only meaning of the term, but who can and probably will write a book. "
― James Purdy , Cabot Wright Begins
24 " The kind of poem I produced in those days was hardly anything more than a sign I made of being alive, of passing or having passed, or hoping to pass, through certain intense human emotions. It was a phenomenon of orientation rather than of art, thus comparable to stripes of paint on a roadside rock or to a pillared heap of stones marking a mountain trail. "
― Vladimir Nabokov , Speak, Memory
25 " The relation to the other is not epistemological, but ethical, and the whole attempt to accomodate or account for the other within the confines of my experience already constitutes a breach of this fundamental ethical relation. The other is precisely that which cannot be the object of my experience in the sense of being completely manifest within it, and so cannot be construed as a phenomenon at all. "
― David R. Cerbone
26 " In 1991, though, began an uprising that would propel those reptilian Republicans from a tiny splinter group into the state’s dominant political faction, that would reduce Kansas Democrats to third-party status, and that would wreck what remained of the state’s progressive legacy. We are accustomed to thinking of the backlash as a phenomenon of the seventies (the busing riots, the tax revolt) or the eighties (the Reagan revolution); in Kansas the great move to the right was a story of the nineties, a story of the present. "
― Thomas Frank , What's the Matter with Kansas? How Conservatives Won the Heart of America
27 " Jealousy is a fever that arises from a stupid, baseless excitement in our unthinking brain.Jealousy is a phenomenon of auto-suggestion.The woman you love has gone to bed with X. You hate X, you hate her, and you have perpetually before your eyes the vision of your loved one and X embracing in an act that fills you with horror.But you too in your time have deceived the woman you love and have done with Y what X did in bed with woman you love.Well, what remains in your skin ,your mind of Mrs Y? Nothing whatever. No more than X left with your woman.In other words, auto suggestion. Do you want evidence of that? Well, then, if you don't know the man, you imagine him to be hateful, offensive, repulsive, and you feel that if you met him you'd kill him.But, if you happen to see his photograph, you begin to realize that it's possible to look at him without horror; and believe me, if you were actually introduced to him you'd approach him with a cordial smile on your lips, look him in the eye without trembling and, if you have reached my degree of perfection, you'd actually be capable of cheerfully patting him on the back and telling him he's a good chap.In a not too distant future, reason and education will have driven home the lesson of the futility of jealousy. "
― Pitigrilli , Cocaine
28 " As a phenomenon, life has a beginning and ending, but life itself doesn’t. So, which one is truly me - a phenomenon that lasts only between birth and death, or life itself that underlies all phenomena? "
― Ilchi Lee , Change: Realizing Your Greatest Potential
29 " Part of our western outlook stems from the scientific attitude and its method of isolating the parts of a phenomenon in order to analyze them. "
30 " We know that Diana Vishneva is a phenomenon of strength and style, and she certainly has earned the right to stretch her talents as best she can. "
31 " We act as if that being of a man or that being of a woman is actually an internal reality or something that is simply true about us, a fact about us, but actually it's a phenomenon that is being produced all the time and reproduced all the time, so to say gender is performative is to say that nobody really is a gender from the start. "
32 " Donald Trump is a phenomenon that foreign countries haven't seen. So it is a shocking experience to them that he came in to office. "
33 " America's state religion, is patriotism, a phenomenon which has convinced many of the citizenry that 'treason' is morally worse than murder or rape. "
―
