41
" reaches a cell wall, it disintegrates into hundreds of individual virus particles, and the broodlings push through the cell wall like hair and float away in the bloodstream of the host. The hatched Ebola particles cling to cells everywhere in the body, and get inside them, and continue to multiply. It keeps on multiplying until areas of tissue all through the body are filled with crystalloids, which hatch, and more Ebola particles drift into the bloodstream, and the amplification continues inexorably until a droplet of the host’s blood can contain a hundred million individual virus particles. After death, the cadaver suddenly deteriorates: the internal organs, having been dead or partially dead for days, have already begun to dissolve, and a sort of shock-related meltdown occurs. The corpse’s connective tissue, skin, and organs, already peppered with dead spots, heated by fever, and damaged by shock, begin to liquefy, and the fluids that leak from the cadaver are saturated with Ebola-virus "
― Richard Preston , The Hot Zone: The Terrifying True Story of the Origins of the Ebola Virus
44
" Ebola Zaire attacks every organ and tissue in the human body except skeletal muscle and bone. It is a perfect parasite because it transforms virtually every part of the body into a digested slime of virus particles. The seven mysterious proteins that, assembled together, make up the Ebola-virus particle, work as a relentless machine, a molecular shark, and they consume the body as the virus makes copies of itself. Small blood clots begin to appear in the bloodstream, and the blood thickens and slows, and the clots begin to stick to the walls of blood vessels. This is known as pavementing, because the clots fit together in a mosaic. The mosaic thickens and throws more clots, and the clots drift through the bloodstream into the small capillaries, where "
― Richard Preston , The Hot Zone: The Terrifying True Story of the Origins of the Ebola Virus
50
" On May 14th, 1796, Jenner scratched the arm of a boy named James Phipps, introducing into his skin a droplet of cowpox pus that he had scraped from a blister on the hand of Sarah Nelmes, a dairy worker. He called this pus “the Vaccine Virus”—the word vaccine is derived from the Latin word for cow. The boy developed a single pustule on his arm, and it healed rapidly. A few months later, Jenner scratched the boy’s arm with lethal infective pus that he had taken from a smallpox patient—today, this is called a challenge trial. The boy did not come down with smallpox. Edward Jenner had discovered and named vaccination—the practice of infecting a person with a mild or harmless virus in order to strengthen his or her immunity to a similar disease-causing virus. “It now becomes too manifest to admit of controversy, that the annihilation of the Small Pox, the most dreadful scourge of the human species, must be the final result of this practice,” Jenner wrote in 1801. "
― Richard Preston , The Demon in the Freezer
53
" bleeds into itself; the heart muscle softens and has hemorrhages into its chambers, and blood squeezes out of the heart muscle as the heart beats, and it floods the chest cavity. The brain becomes clogged with dead blood cells, a condition known as sludging of the brain. Ebola attacks the lining of the eyeball, and the eyeballs may fill up with blood: you may go blind. Droplets of blood stand out on the eyelids: you may weep blood. The blood runs from your eyes down your cheeks and refuses to coagulate. You may have a hemispherical stroke, in which one whole side of the body is paralyzed, which is invariably fatal in a case of Ebola. Even while the body’s internal organs are becoming plugged with coagulated blood, the blood that streams out of the body cannot clot; it resembles whey being squeezed out of curds. The blood has been stripped of its clotting factors. If you put the runny Ebola blood in a test tube and look at it, you see that the blood is destroyed. Its red cells are broken and dead. The blood looks as if it has been buzzed in an electric blender. Ebola kills a great deal of tissue while the host is still alive. It triggers a creeping, spotty necrosis that spreads through all the internal organs. The liver bulges up and turns yellow, begins to liquefy, and then it cracks apart. The cracks run across the liver and deep inside it, and the liver completely dies and goes putrid. The kidneys become jammed with blood clots and dead cells, and cease functioning. As the kidneys fail, the blood becomes toxic with urine. The spleen turns into a single huge, hard blood clot the size of a "
― Richard Preston , The Hot Zone: The Terrifying True Story of the Origins of the Ebola Virus