Home > Topic > strong evidence
1 " It does appear that some parts of our evolutionary process seem inevitable. It is striking that throughout evolutionary history, the eye evolved independently fifty to a hundred times. This is strong evidence for the fact that the different rolls of the dice that have occurred across different species seem to have produced species with eyes regardless of what is going on around them. Lots of other examples illustrate how some features, if they are advantageous, seem to rise to the top of the evolutionary swamp. This is illustrated every time you see the same feature appearing more than once in different parts of the animal kingdom. Dolphins and bats, for example, use echolocation, but they evolved this trait independently at very different points on the evolutionary tree. "
― Marcus du Sautoy , What We Cannot Know: Explorations at the Edge of Knowledge
2 " The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution. "
― , Viruses: Agents of Evolutionary Invention
3 " The FHA's success provides strong evidence that government can and should play a role in the nation's mortgage finance system. It also demonstrates that although government intervention in the economy during the Great Recession was messy, things would have been a lot messier without it. "