" She couldn't get any further at that point. The sky full of stars seemed dead and cold, everything in it the result of the mechanical, indifferent interactions of molecules and particles that would continue for the rest of time whether Lyra lived or died, whether human beings were conscious or unconscious: a vast silent empty indifference, all quite meaningless.
Reason had brought her to this state. She had exalted reason over every other faculty. The result had been - was now - the deepest unhappiness she had ever felt. "

― Philip Pullman , The Secret Commonwealth (The Book of Dust, #2)