" In the first place, a new synthesis never results from a mere adding together of two fully developed branches in biological or mental evolution. Each new departure, each reintegration of what has become separated, involves the breaking down of the rigid, ossified patterns of behaviour and thought. Copernicus failed to do so; he tried to mate the heliocentric tradition with orthodox Aristotelian doctrine, and failed. Newton succeeded because orthodox astronomy had already been broken up by Kepler and orthodox physics by Galileo; reading a new pattern into the shambles, he united them in a new conceptual frame. Similarly, chemistry and physics could only become united after physics had renounced the dogma of the indivisibility and impermeability of the atom, thus destroying its own classic concept of matter, and chemistry had renounced its doctrine of ultimate immutable elements. A new evolutionary departure is only possible after a certain amount of de-differentiation, a cracking and thawing of the frozen structures resulting from isolated, over-specialized development. "

― Arthur Koestler , The Sleepwalkers: A History of Man's Changing Vision of the Universe