" Muller was catapulted into the international fame by his discovery. The effect of radiation on the mutation rate in flies had two immediate implications. First, genes had to be made of matter. Radiation, after all, is merely energy. Frederick Griffith had made genes move between organisms. Muller had altered genes using energy. A gene, whatever it was, was capable of motion, transmission, and of energy-induced change properties generally associated with chemical matter. "