" Protein engineering has moved from a wary adventure on the part of a few pioneering groups in the 1980s to a routine tool used around the world today on a vast range of targets, and with immense power for fine-tuning the properties of enzymes and other proteins for practical applications. In particular, enzyme catalysis has at last gained widespread acceptance as a tool for chemistry, and, because enzyme catalysis avoids the need for high temperatures and pressures and toxic waste streams, it has become the basis of what is now generally known as ‘green chemistry’. One recent indicator of this remarkable shift in the relationship between enzymology and mainstream chemistry was the share in the 2018 Nobel Prize for Chemistry for Professor Frances Arnold at Caltech who has in recent years pioneered major advances in the methodology for efficient development of novel biocatalysts. "

― , Enzymes: A Very Short Introduction