" But scientific progress, he wrote, almost always comes from trying to apply new knowledge to solve problems: ‘significant progress in the solutions of technical problems is frequently made not by a direct approach, but by first setting a goal of high challenge which offers a strong motivation for innovative work, which fires the imagination and spurs men to expend their best efforts, and which acts as a catalyst by including chains of other reactions. "

― Mariana Mazzucato , Mission Economy: A Moonshot Guide to Changing Capitalism