QUOTE : Estradiol—Estradiol is the strongest estrogen; it helps you think clearly. It is produced in the ovaries and has many protective effects, including maintaining bone density, improving growth hormone production and cardiovascular function, keeping your blood from getting “sticky,” supporting cognitive function and mood, assisting in growth hormone release, and improving your lipids profile. Too much estradiol can be associated with estrogen-related cancers, but deficiencies can lead to osteoporosis, heart disease, dementia, and other diseases of aging. Estradiol keeps you looking and feeling young and vibrant. It also provides antiaging protection for the skin. And it even helps prevent weight gain. Researchers at Yale University have found that estradiol suppresses appetite using the same pathways in the brain as leptin, which is one of the hormones that regulate appetite.