" The second development, in 1960, was the development of a new technology that allowed researchers for the first time ever to measure accurately the level of hormones circulating in the bloodstream. It was the invention of Rosalyn Yalow, a medical physicist, and Solomon Berson, a physician, and was called the radioimmunoassay. When Yalow won the Nobel Prize for the work in 1977 (Berson by then was not alive to share it), the Nobel Foundation would describe it aptly as bringing about “a revolution in biological and medical research.” Those interested in obesity could now finally answer the questions about which the pre–World War II European clinicians could only speculate: which hormones were regulating the storage of fat in fat cells and its use for fuel by the rest of the body? Answers began coming with the very first publications out of Yalow and Berson’s laboratory and were swiftly confirmed by others. As it turns out, virtually all hormones work to mobilize fat from fat cells so that it can then be used for fuel. Hormones are signaling our bodies to act—flee or fight, reproduce, grow—and they also signal the fat cells to make available the fuel necessary for these actions. The one dominant exception to this fuel-mobilization signaling is insulin, the same hormone that researchers still assumed in the early 1960s to be deficient in all cases of diabetes. Insulin, Yalow and Berson reported, can be thought of as orchestrating how the body uses or “partitions” the fuel it takes in. "

― Gary Taubes , The Case Against Sugar