" Suppose you have a group of fifty experimental subjects, who you hypothesize (H) are human beings. You observe (O) that one of them is an albino. Now, albinism is extremely rare, affecting no more than one in twenty thousand people. So given that H is correct, the chance you’d find an albino among your fifty subjects is quite small, less than 1 in 400,* or 0.0025. So the p-value, the probability of observing O given H, is much lower than .05. We are inexorably led to conclude, with a high degree of statistical confidence, that H is incorrect: the subjects in the sample are not human beings. "

― Jordan Ellenberg , How Not to Be Wrong: The Power of Mathematical Thinking