" To summarize this point succinctly, self-regulation appears to depend upon neural integration. As we’ll see, optimal relationships are likely to stimulate the growth of integrative fibers in the brain, whereas neglectful and abusive relationships specifically inhibit the healthy growth of neural integration in the young child.18 Even impairments to health that are not experientially derived, such as autism, bipolar disorder, and schizophrenia, have now been shown to reveal impairments to neural integration.19 "

― Daniel J. Siegel , The Developing Mind: How Relationships and the Brain Interact to Shape Who We Are