" Between 10 and 20 years to complete the course, from the first small alterations of character, tremors in the hands and face, emotional disturbance, including – most notably – sudden, uncontrollable alterations of mood, the helpless jerky dance-like movements, intellectual dilapidation, memory failure, agnosia, apraxia, dementia, total loss of muscular control rigidity sometimes, nightmarish hallucinations and a meaningless end. This is how the brilliant machinery of being is undone by the tiniest of faulty cogs, the insidious whisper of ruin, a single bad idea lodged in every cell, on every chromosome four. "
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