" An important point about this intelligence is that it should not be sure ahead of time what must be. It can be prejudiced, and say ‘That is very unlikely; I don’t like that’. Prejudice is different from absolute certainty. I do not mean absolute prejudice – just bias. As long as you are only biased it does not make any difference, because if your bias is wrong a perpetual accumulation of experiments will perpetually annoy you until they cannot be disregarded any longer. They can only be disregarded if you are absolutely sure ahead of time of some precondition that science has to have. In fact it is necessary for the very existence of science that minds exist which do not allow that nature must satisfy some preconceived conditions, like those of our philosopher. "

― Richard P. Feynman , The Character of Physical Law