" Frank went on to tell me that much of the premise of Dune—the magic spice (spores) that allowed the bending of space (tripping), the giant worms (maggots digesting mushrooms), the eyes of the Freman (the cerulean blue of Psilocybe mushrooms), the mysticism of the female spiritual warriors, the Bene Gesserits (influenced by tales of Maria Sabina and the sacred mushroom cults of Mexico)—came from his perception of the fungal life cycle, and his imagination was stimulated through his experiences with the use of magic mushrooms. "

― Paul Stamets , Mycelium Running: How Mushrooms Can Help Save the World