" A study in the Journal of Neuroscience tested pain sensitivity in women at different times during their menstrual cycle—first during their period when estradiol is at its lowest and then when their estradiol levels were at their highest. The women in the study were subjected to a controlled amount of pain and asked to rate the level of their discomfort. At low levels of estradiol, the women reported feeling much more pain than when the hormone was at its highest. The implication is that when your estrogen levels are low, such as during menopause or during the premenstrual or menstrual phase of your cycle, you are likely to feel pain more acutely, which is also likely true for emotional pain. Just one more reason a smart man is especially sensitive at this time! "

― Daniel G. Amen , Unleash the Power of the Female Brain: Supercharging Yours for Better Health, Energy, Mood, Focus, and Sex